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Neuroimaging in Epilepsy$
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Harry Chugani, MD

Print publication date: 2010

Print ISBN-13: 9780195342765

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195342765.001.0001

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Magnetic Resonance Spectroscopy

Magnetic Resonance Spectroscopy

(p.63) Chapter 4 Magnetic Resonance Spectroscopy
Neuroimaging in Epilepsy

Hoby Hetherington

Oxford University Press

Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) enable the noninvasive regional assessment of major metabolites in the human brain including: N-acetyl aspartate (NAA), glutamate, gamma amino butyric acid (GABA) and phosphocreatine (PCr). In epilepsy, neuronal impairment and bioenergetic alterations result in decreased levels of NAA and PCr in both the primary focus and networks involved in seizure propagation. The alterations in NAA and PCr are not due solely to neuronal loss, but are correlated with functional decline and hiostologic changes at a cellular level, suggesting a significant role for bioenergetic impairment in the pathophysiology of epilepsy. Alterations in brain GABA levels have been used to titrate and evaluate the effectiveness of antiepileptic medications targeting the GABAergic system.

Keywords:   magnetic resonance spectroscopy, bioenergetics, N-acetyl aspartate, glutamate, gamma amino butyric acid

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