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Neuroimaging in Epilepsy$
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Harry Chugani, MD

Print publication date: 2010

Print ISBN-13: 9780195342765

Published to Oxford Scholarship Online: January 2011

DOI: 10.1093/acprof:oso/9780195342765.001.0001

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Diffusion MRI in Epilepsy

Diffusion MRI in Epilepsy

(p.92) Chapter 6 Diffusion MRI in Epilepsy
Neuroimaging in Epilepsy

Rajkumar Munian Govindan

Harry T. Chugani

Oxford University Press

Diffusion MRI facilitates the measurement of water diffusion in specific spatial directions and is highly sensitive to microstructural changes in neural tissue. This chapter provides an overview of diffusion MRI and its application in studying the epileptic brain. Using this imaging technique, one is able to study the evolution of subtle microstructural changes in the epileptic focus and in epileptic networks. The directional diffusion information also allows one to perform a virtual construction of white matter pathways in order to evaluate the diffusion changes and morphological characteristics of specific white matter tracts. Using this technique, future studies could further elucidate the role of seizures in causing tissue damage, and the possible relations between microstructural abnormalities and neuro-cognitive decline seen in patients with chronic epilepsy.

Keywords:   diffusion tensor imaging, epilepsy, tractography, anisotropy, ictal, postictal interictal, tract, diffusion, FA, ADC, DTI

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