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Cortical Oscillations in Health and Disease$
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Roger Traub, MD and Miles Whittington, PhD

Print publication date: 2010

Print ISBN-13: 9780195342796

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195342796.001.0001

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Persistent Gamma Oscillations

Persistent Gamma Oscillations

(p.282) 12 Persistent Gamma Oscillations
Cortical Oscillations in Health and Disease

Roger D. Roger

Miles A. Whittington

Oxford University Press

Gamma oscillations can be elicited in hippocampal and neocortical slices, by carbachol and by kainate. Pyramidal neurons fire at low rates, but fast-spiking interneurons fire at near gamma rates. The oscillations require gap junctions, presumably on axons, as the oscillations are still present in a connexin36 knockout (although at reduced power). In a model that accounts for this type of gamma, brief bursts of VFO are generated by the plexus of pyramidal cell axons, that are electrically coupled with one another. This VFO synaptically forces interneurons to fire, and feedback inhibition shuts off the VFO. Neocortical gamma, in at least some regions of cortex, appears to depend on chattering cells as well, but not in the expected fashion (i.e. not as a result of the synaptic output of the chattering cells).

Keywords:   carbachol, kainate, VFO, feedback inhibition, gap junction, chattering cell

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