Epilepsy can be viewed from inter-related clinical and electrical/cellular points of view. Before and during a so-called electrographic seizure, neuronal events become both highly correlated (synchronized) and also organized in time. The latter organization occurs over a wide range of frequencies. Prior to seizures, very fast oscillations (VFO, >70-80 Hz) occur, that are dependent on gap junctions. Understanding how VFO is generated may provide a therapeutic target.
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