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Cortical Oscillations in Health and Disease$
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Roger Traub, MD and Miles Whittington, PhD

Print publication date: 2010

Print ISBN-13: 9780195342796

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195342796.001.0001

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Parkinson’s Disease

Parkinson’s Disease

(p.105) 5 Parkinson’s Disease
Cortical Oscillations in Health and Disease

Roger D. Roger

Miles A. Whittington

Oxford University Press

Parkinson's Disease is associated with loss of brainstem dopaminergic neurons, and loss of dopaminergic innervation of basal ganglia and cortex. The most disabling clinical symptoms are slowness of movement and postural instability. Both in the clinical disorder, and in experimental models, dopaminergic deprivation leads to enhanced beta oscillations (~20 – 30 Hz) in motor and motor-related regions. Interestingly, beta oscillations occuring during cognitive tasks are associated with immobility. Beta oscillations can also be induced in vitro (Chapter 11).

Keywords:   dopamine, beta oscillation, bradykinesia, ventral tegmental area, subthalamic nucleus

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