One factor in schizophrenia may be a decrease in NMDA receptor mediated excitation of interneurons, both acting during brain development and also more acutely. The NMDA receptor antagonist, ketamine, given to normal volunteers, can elicit psychotic symptoms. Ketamine also affects gamma (30 – 70 Hz) and beta oscillations experimentally, in in vitro brain slices. The effects of ketamine, however – whether to enhance or diminish oscillation power, and acting on which frequency range – depend on the brain region in question. There is no pan-cortical phenomenology of oscillations.
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