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Cortical Oscillations in Health and Disease$
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Roger Traub, MD and Miles Whittington, PhD

Print publication date: 2010

Print ISBN-13: 9780195342796

Published to Oxford Scholarship Online: May 2010

DOI: 10.1093/acprof:oso/9780195342796.001.0001

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Cerebellar Ataxia

Cerebellar Ataxia

(p.152) 7 Cerebellar Ataxia
Cortical Oscillations in Health and Disease

Roger D. Roger

Miles A. Whittington

Oxford University Press

Disease processes affecting the cerebellum and its connections, such as can occur in multiple sclerosis, often lead to lack of motor coordination, postural tremor, and tremor on directed movement; these symptoms can be difficult to treat. The cerebellum generates oscillations over a range of frequencies (beta, gamma, very fast) and some of these are coherent with oscillations in thalamus and in muscle. Genetically modified ataxic mice can exhibit short runs of very fast oscillations that are gap junction dependent. Oscillations can also be induced in cerebellar cortex slices: gamma and very fast oscillations both require gap junctions, and gamma also depends on synaptic inhibition.

Keywords:   incoordination, ataxia, gap junction, IPSP, Purkinje cell

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