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NeuroDynamix IIConcepts of Neurophysiology Illustrated by Computer Simulations$
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W. Otto Friesen and Jonathon Friesen

Print publication date: 2009

Print ISBN-13: 9780195371833

Published to Oxford Scholarship Online: February 2010

DOI: 10.1093/acprof:oso/9780195371833.001.0001

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Patch Model

Patch Model

(p.151) II.2 Patch Model
NeuroDynamix II

W. Otto Friesen

Jonathon A. Friesen

Oxford University Press

The Patch model simulates the dynamics of a small piece of cell membrane as observed with the patch-clamp technique. Either individual channels in a small patch of membrane or the macroscopic current observed with the whole cell patch clamp may be simulated. Channels are viewed as all-or-none conductances that are gated by voltage (sodium and potassium channels), by a messenger ligand (ACh channel), or not gated (chloride channel). The experimenter can specify the channel type and the number of channels found in the membrane patch. Properties that are simulated include the random opening of channels, the gating of the channels by membrane potential, the voltage dependence of the currents through the channels, the dependence of single channel currents on channel conductance, and the summation of microscopic currents from many individual, randomly gated channels to yield a noisy macroscopic current.

Keywords:   parameter, variable, patch clamp, ion channel, gating, conductance, current

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