Dopamine and Synaptic Plasticity in Mesolimbic Circuits
Dopamine and Synaptic Plasticity in Mesolimbic Circuits
This chapter reviews current understanding of how dopamine (DA) might modulate glutamatergic synaptic plasticity in mesolimbic brain regions. This topic is examined in the context of in vitro brain slice experiments and plasticity induction in the anesthetized animal. The possibility that DA modulation of glutamatergic signaling could occur in the awake animal and contribute to the expression of motivated behavior is discussed.
Keywords: dopamine, glutamatergic synaptic plasticity, mesolimbic system, motivation behavior
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