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The History of Neuroscience in Autobiography Volume 6$
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Larry R Squire

Print publication date: 2009

Print ISBN-13: 9780195380101

Published to Oxford Scholarship Online: May 2009

DOI: 10.1093/acprof:oso/9780195380101.001.0001

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Hans Thoenen

Hans Thoenen

(p.515) Hans Thoenen
The History of Neuroscience in Autobiography Volume 6

Larry R. Squire

Oxford University Press

This chapter presents an autobiography of Hans Thoenen. Thoenen elucidated the mechanism of action of 6-hydroxydopamine that led to the serendipitous detection of trans-synaptic enzyme induction. Subsequently his laboratory made crucial contributions to the field of neurotrophic factors, including the cloning of brain derived neurotrophic and ciliary neurotrophic factor and the analysis of their physiological functions. His early years, career, and achievements are discussed.

Keywords:   6-hydroxydopamine, cloning, ciliary, trans-synapytic enzyme induction, neurotrophic

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