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The Roots of Cognitive NeuroscienceBehavioral Neurology and Neuropsychology$
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Anjan Chatterjee and H. Branch Coslett

Print publication date: 2013

Print ISBN-13: 9780195395549

Published to Oxford Scholarship Online: January 2014

DOI: 10.1093/acprof:oso/9780195395549.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 28 November 2021

Behavioral and Cognitive Effects of Antiepileptic Drugs

Behavioral and Cognitive Effects of Antiepileptic Drugs

(p.269) Chapter 13 Behavioral and Cognitive Effects of Antiepileptic Drugs
The Roots of Cognitive Neuroscience

Kimford J. Meador

Oxford University Press

Antiepileptic drugs (AEDs) are the major therapeutic modality for seizures and are frequently used for other indications (e.g., pain and psychiatric disorders). Thus, the behavioral and cognitive effects of AEDs including differential effects are important. The risks of AED cognitive effects are increased with certain AEDs, polypharmacy, higher dosage, and higher AED blood levels. AED cognitive effects can be clinically significant since they can impair psychomotor processing speed, sustained attention, memory, dual processing, and quality of life. Special concern should be directed at patients dependent on these skills for work or school. Further, fetal exposure to some AEDs (e.g., valproate) may have long-lasting neurodevelopment consequences. Most AEDs can produce negative behavioral effects, but some can also have positive psychotropic effects (e.g., carbamazepine, lamotrigine, valproate).

Keywords:   antiepileptic drugs, anticonvulsants, cognition, behaviour, teratogenesis

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