Lysosomal Disorders of the Brain: Recent Advances in Molecular and Cellular Pathogenesis and Treatment
Frances Platt and Steven Walkley
Abstract
Lysosomal storage diseases are inherited metabolic disorders characterized by severe pathology, typically involving the brain. Although individually rare, they collectively represent a significant group of diseases that primarily present in early infancy or childhood. In recent years, considerable progress has been made in understanding the molecular mechanisms that lead to disordered function of the lysosomal system and to lysosomal storage. Unravelling the basis for these diseases is providing unique insight into the normal biology of cells and pointing the way to the development of therapeu ... More
Lysosomal storage diseases are inherited metabolic disorders characterized by severe pathology, typically involving the brain. Although individually rare, they collectively represent a significant group of diseases that primarily present in early infancy or childhood. In recent years, considerable progress has been made in understanding the molecular mechanisms that lead to disordered function of the lysosomal system and to lysosomal storage. Unravelling the basis for these diseases is providing unique insight into the normal biology of cells and pointing the way to the development of therapeutic strategies for their treatment. This book details recent advances in the molecular and cellular pathologies of these diseases and in the development of effective therapies. After an overview of the biology of the endosomal-lysosomal system and the types of diseases resulting from defects in this system, the book describes in detail the molecular mechanisms of storage, model systems and pathophysiological mechanisms, and finally, new advances toward treatment.
Keywords:
metabolic disorders,
severe pathology,
infancy,
childhood,
lysosomal storage,
lysosomal system,
therapeutic strategies,
molecular mechanisms
Bibliographic Information
| Print publication date: 2004 |
Print ISBN-13: 9780198508786 |
| Published to Oxford Scholarship Online: September 2009 |
DOI:10.1093/acprof:oso/9780198508786.001.0001 |
Authors
Affiliations are at time of print publication.
Frances Platt, editor
Glycobiology Institute, Department of Biochemistry, University of Oxford, UK
Steven Walkley, editor
Department of Neuroscience, Albert Einstein College of Medicine, New York, USA
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