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Neurobiology of Nociceptors - Oxford Scholarship Online
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Neurobiology of Nociceptors

Carlos Belmonte and Fernando Cervero

Abstract

This is a comprehensive review of all aspects of nociceptor function, including the structure of nociceptor endings, their neurochemistry, and evolutionary considerations. It deals with the functional properties of nociceptors innervating different organs and the biophysical mechanisms underlying the transduction process in nociceptors. There are sections on how nociceptor function is modified by nerve injury and regeneration and on its physiopathology.

Keywords: nociceptor function, nociceptor endings, neurochemistry, functional properties, nociceptors, biophysical mechanisms, transduction, nerve injury, regeneration, physiopathology

Bibliographic Information

Print publication date: 1996 Print ISBN-13: 9780198523345
Published to Oxford Scholarship Online: March 2012 DOI:10.1093/acprof:oso/9780198523345.001.0001

Authors

Affiliations are at time of print publication.

Carlos Belmonte, editor
University of Alicante

Fernando Cervero, editor
University of Alcala de Henares

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Contents

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Front Matter

Title Pages

Preface

Contributors

Principles of classification and nomenclature relevant to studies of nociceptive neurones

Lynn Bruce

Part 1 Basic aspects of nociceptor function

1 Pain and the discovery of nociceptors

Perl Edward R.

2 Structure of nociceptor ‘endings’

Kruger Lawrence, and Halata Zdenek

3 Neurochemistry of cutaneous nociceptors

Lawson Sally N.

4 Comparative and evolutionary aspects of nociceptor function

Walters Edgar T.

Part 2 Nociceptors and the signalling of injury

5 Cutaneous nociceptors

Campbell James N., and Meyer Richard A.

6 Corneal nociceptors

Belmonte Carlos, and Gallar Juana

7 Nociceptors in skeletal muscle and their reaction to pathological tissue changes

Mense Siegfried

8 Neurobiology of articular nociceptors

Schaible Hans-Georg, and Schmidt Robert F.

9 Visceral nociceptors

Cervero Fernando

Part 3 Transduction mechanisms and sensitization

10 Signal transduction in nociceptors: general principles

Belmonte Carlos

11 Chemical excitation and sensitization in nociceptors

Kress Michaela, and Reeh Peter W.

12 Intracellular messengers and signal transduction in nociceptors

Bevan Stuart

13 Sensitization of polymodal receptors

Kumazawa Takao

Part 4 Functions of nociceptors

14 Functional properties of human cutaneous nociceptors and their role in pain and hyperalgesia

TorebjÖrk H.E., Schmelz M., and Handwerker H.O.

15 Neural mechanisms of primary hyperalgesia

Meyer Richard A., Raja Srinivasa N., and Campbell James N.

16 Secondary cutaneous dysaesthesiae

Lamotte Robert H.

17 Efferent function of nociceptors

Lynn Bruce

18 Nociceptors and neuroimmune interactions

Stein Christoph

Part 5 Nociceptor plasticity

19 Development of the nociceptor phenotype: role of nerve growth factor

Mendell Lorne M.

20 Properties of regenerated nociceptor afferents

Lisney S.J.W.

21 Pathophysiology of human nociceptor function

Ochoa JosÈ L., Serra Jordi, and Campero Mario

End Matter

Index