- Title Pages
- Dedication
- Contributors
- Abbreviations
- 1 Death and survival in the nervous system
- 2 Axotomy and mechanical damage
- 3 Metabolic damage
- 4 Inflammation and demyelination
- 5 Infection
- 6 Neurodegenerative disease
- 7 Neuroprotection
- 8 Steroids
- 9 Trophic factors
- 10 Control of inflammation
- 11 Peripheral nerve regeneration
- 12 Failure of CNS regeneration
- 13 Anatomical plasticity
- 14 Biochemical plasticity
- 15 Remyelination
- 16 Coma
- 17 Motor, sensory, and autonomic function
- 18 Cognition
- 19 Psychiatric assessment
- 20 Pharmacological management
- 21 Neuropsychological rehabilitation
- 22 Axon regeneration in the CNS
- 23 Primary neuronal transplantation
- 24 Glial transplantation
- 25 Stem cells
- 26 Gene therapy
- Appendix 1 Alzheimer's disease
- Appendix 2 Amyotrophic lateral sclerosis (ALS)/Motor neurone disease
- Appendix 3 Creutzfeldt-Jakob disease (CJD)
- Appendix 4 Epilepsy
- Appendix 5 Huntington's disease
- Appendix 6 Multiple sclerosis
- Appendix 7 Parkinson's disease
- Appendix 8 Spinal-cord injury
- Appendix 9 Stroke
- References
- Index
Peripheral nerve regeneration
Peripheral nerve regeneration
- Chapter:
- (p.145) 11 Peripheral nerve regeneration
- Source:
- Brain Damage, Brain Repair
- Author(s):
James W. Fawcett
Anne E. Rosser
Stephen B. Dunnett
- Publisher:
- Oxford University Press
Mammals have retained the ability to regenerate axons in the peripheral nervous system (PNS) and, if properly treated, can regain much of the function that is lost after peripheral nerve damage. Not only do the axons regenerate in the periphery, but they restore functional motor connections with muscles, and functional sensory connections with the skin. Nevertheless, peripheral nerve repair is seldom perfect, due both to problems of axon guidance and to other factors that can limit regeneration. There are, therefore, several problems that need to be solved before a regenerated peripheral nerve can completely restore normal function.
Keywords: nerve regeneration, axons, peripheral nervous system, peripheral nerve damage, functional motor connections, functional sensory connections
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- Title Pages
- Dedication
- Contributors
- Abbreviations
- 1 Death and survival in the nervous system
- 2 Axotomy and mechanical damage
- 3 Metabolic damage
- 4 Inflammation and demyelination
- 5 Infection
- 6 Neurodegenerative disease
- 7 Neuroprotection
- 8 Steroids
- 9 Trophic factors
- 10 Control of inflammation
- 11 Peripheral nerve regeneration
- 12 Failure of CNS regeneration
- 13 Anatomical plasticity
- 14 Biochemical plasticity
- 15 Remyelination
- 16 Coma
- 17 Motor, sensory, and autonomic function
- 18 Cognition
- 19 Psychiatric assessment
- 20 Pharmacological management
- 21 Neuropsychological rehabilitation
- 22 Axon regeneration in the CNS
- 23 Primary neuronal transplantation
- 24 Glial transplantation
- 25 Stem cells
- 26 Gene therapy
- Appendix 1 Alzheimer's disease
- Appendix 2 Amyotrophic lateral sclerosis (ALS)/Motor neurone disease
- Appendix 3 Creutzfeldt-Jakob disease (CJD)
- Appendix 4 Epilepsy
- Appendix 5 Huntington's disease
- Appendix 6 Multiple sclerosis
- Appendix 7 Parkinson's disease
- Appendix 8 Spinal-cord injury
- Appendix 9 Stroke
- References
- Index
