Jump to ContentJump to Main Navigation
Brain Damage, Brain Repair$
Users without a subscription are not able to see the full content.

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021

Failure of CNS regeneration

Failure of CNS regeneration

(p.155) 12 Failure of CNS regeneration
Brain Damage, Brain Repair

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Oxford University Press

Axons in the mammalian peripheral nervous system (PNS) regenerate well. Axons in the adult mammalian central nervous system (CNS), however, do not spontaneously regenerate, with the result that any injury that cuts axons, such as spinal-cord injury, will not recover. Clearly a central feature of CNS repair will have to be the induction of axon regeneration. In principle, axon growth is a collaborative process that involves a dialogue between the axon and the environment it is trying to penetrate. Whether an axon will regenerate or not, therefore, depends on the regenerative efforts made by the axon, on the inhibitory or permissive molecules in the environment, and on the receptors for these molecules on the axonal surface. This chapter examines these various factors and their effects on CNS axon regeneration.

Keywords:   peripheral nervous system, axon regeneration, central nervous system, CNS regeneration, axonal surface, permissive molecules

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .