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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021



By Robin Franklin

(p.205) 15 Remyelination
Brain Damage, Brain Repair

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Oxford University Press

Demyelination is unusual in the spectrum of pathological processes that affect the central nervous system (CNS) in that it may be followed by a spontaneous regenerative process. This process, termed remyelination, involves re-investing demyelinated axons with new myelin sheaths (or internodes), and has been described in a number of experimental models, as well as in naturally-occurring demyelinating disease—most notably the acute lesions of multiple sclerosis. Remyelination allows the axon to transmit action potentials by saltatory conduction, a property that is lost in demyelination.

Keywords:   demyelination, pathological processes, central nervous system, regenerative process, remyelination, acute lesions

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