Jump to ContentJump to Main Navigation
Brain Damage, Brain Repair$
Users without a subscription are not able to see the full content.

James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021

Axotomy and mechanical damage

Axotomy and mechanical damage

(p.15) 2 Axotomy and mechanical damage
Brain Damage, Brain Repair

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Oxford University Press

Almost any form of damage to the nervous system will damage axons. Axons are in a uniquely vulnerable position compared with most other cell components in that they are long and, therefore, for the most part physically far removed from their cell body. Yet they are entirely dependent on the cell body for the provision of the proteins required for homeostasis and function. Cutting an axon disconnects that part of it distal to the lesion from its source of protein synthesis and eventual death is, therefore, inevitable. The myelin that surrounds a dying axon is also inevitably compromised. The degeneration of the distal portion of a cut axon, together with the degeneration of its myelin, was originally described by Waller in 1850, and is now termed Wallerian degeneration.

Keywords:   axotomy, mechanical damage, nervous system, homeostasis, protein synthesis, Wallerian degeneration

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .