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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021

Glial transplantation

Glial transplantation

Robin J.M. Franklin

(p.335) 24 Glial transplantation
Brain Damage, Brain Repair

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Oxford University Press

In parallel with the development of neuronal transplantation, glial cell transplantation has rapidly evolved as an experimental technique to study cellular interactions during glial development, and as a potential strategy for repair to remyelinate areas of persistent demyelination in clinical conditions. An important feature of all glial cell transplantation models is that the host environment into which cells are transplanted must contain non-myelinated axons of an appropriate diameter for myelination. Such environments can arise for a variety of reasons, and many have been used as host environments in transplantation studies, such as the non-myelinated axons of the retina or during development before myelination is complete. However, the majority of transplantation studies have been undertaken using one of two models.

Keywords:   glial cell transplantation, cellular interactions, glial development, demyelination, clinical condition, myelination

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