- Title Pages
- Dedication
- Contributors
- Abbreviations
- 1 Death and survival in the nervous system
- 2 Axotomy and mechanical damage
- 3 Metabolic damage
- 4 Inflammation and demyelination
- 5 Infection
- 6 Neurodegenerative disease
- 7 Neuroprotection
- 8 Steroids
- 9 Trophic factors
- 10 Control of inflammation
- 11 Peripheral nerve regeneration
- 12 Failure of CNS regeneration
- 13 Anatomical plasticity
- 14 Biochemical plasticity
- 15 Remyelination
- 16 Coma
- 17 Motor, sensory, and autonomic function
- 18 Cognition
- 19 Psychiatric assessment
- 20 Pharmacological management
- 21 Neuropsychological rehabilitation
- 22 Axon regeneration in the CNS
- 23 Primary neuronal transplantation
- 24 Glial transplantation
- 25 Stem cells
- 26 Gene therapy
- Appendix 1 Alzheimer's disease
- Appendix 2 Amyotrophic lateral sclerosis (ALS)/Motor neurone disease
- Appendix 3 Creutzfeldt-Jakob disease (CJD)
- Appendix 4 Epilepsy
- Appendix 5 Huntington's disease
- Appendix 6 Multiple sclerosis
- Appendix 7 Parkinson's disease
- Appendix 8 Spinal-cord injury
- Appendix 9 Stroke
- References
- Index
Gene therapy
Gene therapy
With Stacey Efstathiou
- Chapter:
- (p.357) 26 Gene therapy
- Source:
- Brain Damage, Brain Repair
- Author(s):
James W. Fawcett
Anne E. Rosser
Stephen B. Dunnett
- Publisher:
- Oxford University Press
Genetic engineering may be defined as the development of techniques to manipulate the genotype of cells or organisms in order to modify their phenotype. Gene therapy is the use of those techniques to alleviate injury, repair damage, or change the course of a disease. These techniques are potentially applicable to all living cells, not just cells of the nervous system, and indeed much of what we presently know about genetic engineering and gene therapy comes from the study of other cells, organs, and systems of the body, such as identifying and manipulating genes that predispose to cell proliferation and cause cancer (‘oncogenes’). Gene therapy can have various goals. The two major ones are the correction of genetic disease, and the delivery of genes to the nervous system to alter a disease process.
Keywords: genetic engineering, genotypes, phenotype, living cells, nervous system, cell proliferation, genetic disease
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- Title Pages
- Dedication
- Contributors
- Abbreviations
- 1 Death and survival in the nervous system
- 2 Axotomy and mechanical damage
- 3 Metabolic damage
- 4 Inflammation and demyelination
- 5 Infection
- 6 Neurodegenerative disease
- 7 Neuroprotection
- 8 Steroids
- 9 Trophic factors
- 10 Control of inflammation
- 11 Peripheral nerve regeneration
- 12 Failure of CNS regeneration
- 13 Anatomical plasticity
- 14 Biochemical plasticity
- 15 Remyelination
- 16 Coma
- 17 Motor, sensory, and autonomic function
- 18 Cognition
- 19 Psychiatric assessment
- 20 Pharmacological management
- 21 Neuropsychological rehabilitation
- 22 Axon regeneration in the CNS
- 23 Primary neuronal transplantation
- 24 Glial transplantation
- 25 Stem cells
- 26 Gene therapy
- Appendix 1 Alzheimer's disease
- Appendix 2 Amyotrophic lateral sclerosis (ALS)/Motor neurone disease
- Appendix 3 Creutzfeldt-Jakob disease (CJD)
- Appendix 4 Epilepsy
- Appendix 5 Huntington's disease
- Appendix 6 Multiple sclerosis
- Appendix 7 Parkinson's disease
- Appendix 8 Spinal-cord injury
- Appendix 9 Stroke
- References
- Index
