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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 05 March 2021



With Roger Barker and Steve Wharton

(p.57) 5 Infection
Brain Damage, Brain Repair

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Oxford University Press

Infectious agents can cause a host of disorders within the nervous system, from fulminant bacterial meningitis to slow viral infections that underlie some neurodegenerative conditions. This chapter concentrates on the main pathogenic mechanisms of infective disorders rather than their neuropathological findings. These mechanisms involve direct invasion and damage by the infective organism, exotoxins, and the recruitment of an immune response that, whilst attempting to rid the body of the infection, can also damage the nervous system. Many, if not all, infections mediate their effect through a number of different mechanisms, one of which usually predominates. For clarity, these separate processes are discussed individually with reference to specific disease examples.

Keywords:   nervous system, infectious agents, bacterial meningitis, pathogenic mechanisms, infective disorders, immune response

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