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Brain Damage, Brain Repair$
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James W. Fawcett, Anne E. Rosser, and Stephen B. Dunnett

Print publication date: 2002

Print ISBN-13: 9780198523376

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198523376.001.0001

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(p.107) 7 Neuroprotection
Brain Damage, Brain Repair

James W. Fawcett

Anne E. Rosser

Stephen B. Dunnett

Oxford University Press

Excitoxic damage, metabolic imbalance, oxidative stress, and calcium influx are each capable of inducing cell death by both necrotic and apoptotic mechanisms. If these various mechanisms contribute, separately and together, to neurodegeneration, then a rational strategy for treatment must be to search for ways of blocking the individual components of the cascade that leads to death. One of the major events in the cycle of excitotoxicity and cell death is the influx of calcium, and the consequent imbalance of intracellular homeostasis leading to cell death. This is particularly true in stroke, where calcium imbalance has been seen to provide an important component in the development and spread of the penumbral damage.

Keywords:   neurodegeneration, metabolic imbalance, cell death, intracellular homeostasis, calcium imbalance, stroke

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