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Beyond NeurotransmissionNeuromodulation and its Importance for Information Processing$
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Paul Katz

Print publication date: 1999

Print ISBN-13: 9780198524243

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198524243.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 17 October 2021

The messenger is not the message; or is it?

The messenger is not the message; or is it?

(p.29) 2 The messenger is not the message; or is it?
Beyond Neurotransmission

Barry A. Trimmer

Oxford University Press

This chapter begins by describing neural coding systems (the ‘messages’) thought to take part in information processing in the brain. It then discusses the possible roles played by neurotransmitters in transferring or integrating signals at synapses. Particular emphasis is placed on the complex interplay that can occur between messages and messengers even at the simplest synapses involving a single transmitter and a single receptor subtype. An argument is also made that transmitters are relatively poor indicators of signaling function. It is more appropriate to regard receptors and their associated cellular effects as the primary mediators of information processing in the CNS. Finally, the importance of these interactions are discussed in the context of neurotransmission and neuromodulation.

Keywords:   coding systems, information processing, neurotransmitters, synapses, signaling function, neuromodulation, CNS

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