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Brain, Perception, MemoryAdvances in Cognitive Neuroscience$
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Johan J. Bolhuis

Print publication date: 2000

Print ISBN-13: 9780198524823

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198524823.001.0001

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Genetic strategies for the study of hippocampal-based memory storage

Genetic strategies for the study of hippocampal-based memory storage

(p.163) 10 Genetic strategies for the study of hippocampal-based memory storage
Brain, Perception, Memory

Danny G. Winder

Eric R. Kandel

Oxford University Press

This chapter is a review of recent genetic approaches to the study of learning and memory. With modern genetic techniques, individual genes can be ‘knocked out’ or, alternatively, overexpressed, and the effects of these manipulations on behaviour or on properties of neurons can be measured. This chapter discusses genetic approaches to long-term potentiation (LTP), where the genes coding for individual proteins that are thought to play a role in some stage of LTP can be deleted or overexpressed. Furthermore, it is important to realize that there is not a one-to-one relationship between a gene and behaviour. This chapter discusses ‘second generation’ genetic techniques, where there is a much higher degree of spatial and temporal specificity of the genetic manipulation. It is hoped that these more sophisticated genetic techniques, together with contemporary pharmacological approaches, can shed more light on the mechanisms underlying LTP, and also of those underlying memory.

Keywords:   genetic approaches, LTP, temporal specificity, genetic manipulation, pharmacological approaches

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