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Coronary Heart Disease EpidemiologyFrom aetiology to public health$
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Michael Marmot and Paul Elliott

Print publication date: 2005

Print ISBN-13: 9780198525738

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198525738.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 08 August 2020

Serum homocysteine and coronary heart disease

Serum homocysteine and coronary heart disease

(p.239) Chapter 16 Serum homocysteine and coronary heart disease
Coronary Heart Disease Epidemiology

D. S. Wald

M. R. Law

N. J. Wald

J. K. Morris

Oxford University Press

This chapter discusses the link between serum homocysteine and coronary heart disease (CHD). Genetic studies show a moderately higher risk of CHD for a moderately higher level of serum homocysteine. Prospective studies show a positive association between serum homocysteine and cardiovascular disease after allowance for confounding. Although these two types of study are susceptible to different sources of error, they show quantitatively similar associations, a result that is unlikely to have occurred through different potential sources of confounding acting independently. The homocystinurias cause high serum homocysteine levels and high risks of premature cardiovascular disease, and lowering serum homocysteine reduces this high risk. These observations provide a compelling case for a cause and effect relationship between homocysteine and CHD and, therefore, a protective role for folic acid on CHD prevention.

Keywords:   cardiovascular disease, CHD, folic acid, homocysteine levels

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