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Coronary Heart Disease EpidemiologyFrom aetiology to public health$
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Michael Marmot and Paul Elliott

Print publication date: 2005

Print ISBN-13: 9780198525738

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198525738.001.0001

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Women and cardiovascular heart disease

Women and cardiovascular heart disease

(p.331) Chapter 22 Women and cardiovascular heart disease
Coronary Heart Disease Epidemiology

L. H. Kuller

Oxford University Press

This chapter assesses the substantially lower incidence and mortality due to coronary heart disease (CHD) for women as compared to men. It considers three major current hypotheses to explain these differences: (i) the lower risk among women is due to hormonal differences or tissue-specific hormone receptors; (ii) differences in the distribution of body fat and subsequent metabolic changes, including insulin resistance and distribution of lipoprotein particles, account for the differences in coronary atherosclerosis and clinical CHD among men and women; and (iii) variations in immune response and inflammation are important determinants of differences in CHD between men and women.

Keywords:   CHD, cardiovascular disease, sex differences, coronary atherosclerosis

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