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Coronary Heart Disease EpidemiologyFrom aetiology to public health$
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Michael Marmot and Paul Elliott

Print publication date: 2005

Print ISBN-13: 9780198525738

Published to Oxford Scholarship Online: September 2009

DOI: 10.1093/acprof:oso/9780198525738.001.0001

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Emergence of risk factors in children

Emergence of risk factors in children

(p.591) Chapter 34 Emergence of risk factors in children
Coronary Heart Disease Epidemiology

D. R. Labarthe

Oxford University Press

This chapter discusses the ‘emergence’ of risk factors for atherosclerotic and hypertensive diseases in children and adolescents. The emergence of cardiovascular risk factors in childhood and adolescence is characterized in general by (a) a progressive shift in risk factor distributions with increasing age toward undesirable levels; (b) a tendency for clustering of multiple factors within individual persons; (c) tracking of risk factor values at the higher-risk extreme; and (d) an association with the extent and severity of atherosclerotic lesions observed well before adulthood. Variation in the trajectories of change in mean values of specific risk factors — such as distinct components of blood lipids, blood pressure, or blood glucose and insulin concentrations — indicates some complexity in these patterns and suggests that they may differ in some important aspects of causation and prevention.

Keywords:   coronary heart disease, cardiovascular disease, children's health, risk factor distributions, clustering

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