Jump to ContentJump to Main Navigation
Cephalopod NeurobiologyNeuroscience Studies in Squid, Octopus and Cuttlefish$
Users without a subscription are not able to see the full content.

N. Joan Abbott, Roddy Williamson, and Linda Maddock

Print publication date: 1995

Print ISBN-13: 9780198547907

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198547907.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 14 May 2021

The nervous system of Loligo pealei provides multiple models for analysis of organelle motility

The nervous system of Loligo pealei provides multiple models for analysis of organelle motility

(p.15) 2 The nervous system of Loligo pealei provides multiple models for analysis of organelle motility
Cephalopod Neurobiology

Philip L. Leopold

Jen-Wei Lin

Mutsuyuki Sugimori

Rodolfo Llinás

Scott T. Brady

Oxford University Press

This chapter discusses the use of the squid giant axon and giant synapse in the study of organelle motility. Special attention is paid to the construction of the model systems, and each preparation is illustrated with an example of the model's utility in research on translocating organelles. The popularity of the squid giant axon for electrophysiological studies was derived mainly from unique features of the squid nervous system. The absence of myelin in cephalopods led to the development of unusually large axons in the highly mobile squid. In turn, these giant axons required synaptic contact of similar magnitude to assure proper coupling of pre- and postsynaptic action potentials at a synapse. The giant axon and the giant synapse have taught the principles regarding the enzymology, pharmacology and biochemistry of organelle transport. The squid nervous system has continued to provide insights into neuronal cell biology, in part through development of novel preparations for dissection of cellular mechanisms. Two of these preparations have proven to be invaluable for the study of motility in the axon and presynaptic terminal. Isolated axoplasm from the squid giant axon may be experimentally manipulated by perfusion with suitable buffers, and materials can be microinjected into the presynaptic terminal of the giant synapse during intracellular recording of electrical properties. Both experimental models are discussed in this chapter with reference to their utility in studying the mechanism of organelle transport.

Keywords:   squid giant axon, giant synapse, organelle motility, translocating organelles, presynaptic terminal, axoplasm

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .