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Cephalopod NeurobiologyNeuroscience Studies in Squid, Octopus and Cuttlefish$
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N. Joan Abbott, Roddy Williamson, and Linda Maddock

Print publication date: 1995

Print ISBN-13: 9780198547907

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198547907.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 03 December 2020

The detection and properties of electrogenic Na+–K+ transport in the squid axon membrane

The detection and properties of electrogenic Na+–K+ transport in the squid axon membrane

Chapter:
(p.53) 4 The detection and properties of electrogenic Na+–K+ transport in the squid axon membrane
Source:
Cephalopod Neurobiology
Author(s):

U. Kishimoto

I. Inoue

I. Tsutsui

T. Ohkawa

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198547907.003.0036

This chapter discusses the detection and properties of electronic Na+−K+ transport in the squid axon membrane. The Na pump in the plasma membrane of animal cells mediates uphill transport of Na+ and K+. A number of investigators have sought experimental evidence for the Na/K pumping rate as a function of the membrane potential in a variety of cells and tissues. The occlusion of Na+ at the external surface is enhanced greatly with the decrease of external Na+ concentration and that occlusion of K+ is also greatly enhanced with the decrease of external K+ concentration. This seems to be a primary condition for the enzyme to pump in or pump out the ligand. The enzyme seems to be so designed as to adjust its structure for the change in ligand concentration and to continue its pumping function, even though its i p -V characteristic shifts along the voltage axis. Changes of rate constants in the two state model with external K+ and Na+ concentrations are described in the chapter. If a similar mechanism is involved at the inner surface of the enzyme, changes of rate constants with internal K+ and Na+ concentrations can be anticipated. What can be expected with a decrease of internal Na+ concentration are a great increase of r 21, almost no change of r 12, decrease of k 0 12 and an increase of k 0 21. On the other hand, what can be expected with a decrease of internal K+ concentration are a great increase of r 12, almost no change of r 21, a decrease of k 0 12 and a great decrease of k 0 21. However, these remain to be proved.

Keywords:   Na+−K+ transport, ligand, squid axon membrane, plasma membrane, K+ concentration, Na+ concentration

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