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Cephalopod NeurobiologyNeuroscience Studies in Squid, Octopus and Cuttlefish$
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Cephalopod Neurobiology: Neuroscience Studies in Squid, Octopus and Cuttlefish

N. Joan Abbott, Roddy Williamson, and Linda Maddock

Print publication date: 1995

Print ISBN-13: 9780198547907

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198547907.001.0001

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Studies of the kinetics of the ionic and gating currents in the axons of Loligo forbesi as a guide to modelling of the sodium channel

Studies of the kinetics of the ionic and gating currents in the axons of Loligo forbesi as a guide to modelling of the sodium channel

Chapter:
6 Studies of the kinetics of the ionic and gating currents in the axons of Loligo forbesi as a guide to modelling of the sodium channel
Source:
Cephalopod Neurobiology
Author(s):

Richard D. Keynes

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198547907.003.0061

This chapter summarizes the coming together of a new model of the voltage-gated sodium channel that successfully reconciles almost all the data obtained in recent years from a variety of experimental approaches. This was achieved by exploiting to the full the superlative temporal resolution that can be achieved in recording the ionic and gating currents in the squid giant axon, and by relating the results to Numa's structural evidence that each channel is controlled by four voltage-sensors arranged in parallel. The study of gating currents generated by charge movements accompanying molecular conformational changes in voltage-dependent ion channel proteins provides important information for understanding the structure function relationships of these channels. The ultimate test of any model of the sodium channel must be to insert parameters based strictly on measurements of the gating current, and to demonstrate that this yields correct predictions of the macroscopic ionic current, that is to say for the behaviour of the two open states. The preliminary exercise of this kind was reported by Keynes (1991) and on a simplified computer program, which allowed for an inadequate number of states and left out of account the possible effect of co-operativity in the activation of the system (Keynes 1990). It therefore provided no more than a qualitative indication that the approach described in this chapter is on sound lines. A properly rigorous examination of the model is yet to be conducted.

Keywords:   voltage gated, sodium channel, ionic currents, gating currents, macroscopic ionic current, squid giant axon

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