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The Orbitofrontal Cortex - Oxford Scholarship Online
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The Orbitofrontal Cortex

David Zald and Scott Rauch


The orbitofrontal cortex (OFC) comprises the ventral surface of the frontal lobe, and is critical for functions ranging from olfaction and emotion to learning and behavioral flexibility. Since the time of Phineas Gage, this enigmatic brain region has intrigued clinicians due to its association with personality. Recent research has started to unmask the specific operational principles of the area. Simultaneously, advances in the clinical neurosciences increasingly implicate the OFC and adjacent ventral frontal regions in a variety of psychiatric and neurological conditions including anxiety, mo ... More

Keywords: orbitofrontal, orbital frontal, frontal, prefrontal, neuroanatomy, neuroimaging, neuropsychology, emotion, reward

Bibliographic Information

Print publication date: 2006 Print ISBN-13: 9780198565741
Published to Oxford Scholarship Online: February 2010 DOI:10.1093/acprof:oso/9780198565741.001.0001


Affiliations are at time of print publication.

David Zald, editor
Assistant Professor of Psychology, Vanderbilt University

Scott Rauch, editor
Associate Chief of Psychiatry for Neuroscience Research, Director, Division of Psychiatric Neuroscience Research & Neurotherapeutics, Director, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital; Associate Professor of Psychiatry, Harvard Medical School

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Part 1 Anatomy

Part 2 Functions and methods

Chapter 6 The chemical senses

Jay A. Gottfried, Dana M. Small, and David H. Zald

Chapter 11 Memory processes and the orbitofrontal cortex

Matthias Brand, and Hans J. Markowitsch

Chapter 14 Intracranial electrophysiology of the human orbitofrontal cortex

Ralph Adolphs, Hiroto Kawasaki, Hiroyuki Oya, and Matthew A. Howard

Chapter 16 Neurochemical modulation of orbitofrontal cortex function

Trevor W. Robbins, Luke Clark, Hannah Clarke, and Angela C. Roberts

Part 3 Neuropsychiatry

Chapter 19 The orbitofrontal cortex in drug addiction

Rita Z. Goldstein, Nelly Alia-Klein, Lisa A. Cottone, and Nora D. Volkow

Chapter 20 The orbitofrontal cortex and anxiety disorders

Mohammed R. Milad, and Scott L. Rauch

Chapter 21 The role of the ventral prefrontal cortex in mood disorders

Carolyn A. Fredericks, Jessica H. Kalmar, and Hilary P. Blumberg

Chapter 24 Frontotemporal dementia and the orbitofrontal cortex

Po H. Lu, Negar Khanlou, and Jeffrey L. Cummings

End Matter