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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2007

Print ISBN-13: 9780198566564

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198566564.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 28 January 2021

Molecular determinants of dendrite and spine development

Molecular determinants of dendrite and spine development

(p.95) Chapter 4 Molecular determinants of dendrite and spine development

Franck Polleux

Anirvan Ghosh

Oxford University Press

Information processing in neurons is critically dependent on dendritic morphology. The overall extent and orientation of dendrites determines the kinds of input a neuron receives. Fine dendritic appendages called spines act as subcellular compartments devoted to processing synaptic information, and the dendritic branching pattern determines the efficacy with which synaptic information is transmitted to the soma. The development of the dendritic tree is influenced by a number of factors. Studies in Drosophila have identified key components of the genetic program that regulates dendritic morphogenesis. Parallel studies in vertebrates have revealed that extracellular signals and neuronal activity exert a major influence on the growth and branching of dendrites and the formation of dendritic spines. The identification of genes that mediate these processes is providing important insight into the molecular mechanisms of dendritic morphogenesis.

Keywords:   dendritic morphology, dendritic spines, synaptic information, subcellular compartments, genetic program, spine development

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