Organization and regulation of the postsynaptic density
Organization and regulation of the postsynaptic density
This chapter summarizes the molecular organization of the PSD of neurons in the mammalian central nervous system (CNS), with a specific emphasis on the regulation of ionotropic glutamate receptors (GluRs) in development and plasticity. Various studies have revealed hundreds of molecules associated with the PSD, suggesting daunting complexity in its functional organization. Nonetheless, several approaches have revealed a laminar scaffolding arrangement within the PSD responsible for organizing functionally coupled synaptic proteins. Furthermore, these scaffolding components play a central role in linking the molecular machinery that is responsible for the dynamic regulation of neurotransmission in development and synaptic plasticity, and as such are critically involved in learning and memory.
Keywords: postsynaptic density, neurons, central nervous system, ionotropic glutamate receptors, synaptic proteins, synaptic plasticity
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