Subcellular distribution of neurotransmitter receptors and voltage-gated ion channels
Subcellular distribution of neurotransmitter receptors and voltage-gated ion channels
This chapter describes the subcellular distribution of glutamate and GABA receptors and voltage-activated channels on the neuronal surface, as detected with a variety of light and electron-microscopic techniques. Ionotropic glutamate and GABAA receptors are concentrated at glutamatergic and GABAergic synapses, respectively, on the somatodendritic domains of nerve cells. Different AMPA receptor subtypes are selectively targeted to functionally distinct glutamatergic synapses of a single cell. Furthermore, synaptic AMPA receptor number and density are also highly regulated at a single cell level.
Keywords: subcellular distribution, glutamate, GABA receptors, voltage-activated channels, somatodendritic domains, nerve cells
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