- Title Pages
- Foreword
- Preface
- Contributors
- Abbreviations
- Chapter 1 Dendrite structure
- Chapter 2 Evolution and scaling of dendrites
- Chapter 3 Dendrite development
- Chapter 4 Molecular determinants of dendrite and spine development
- Chapter 5 RNA targeting, trafficking, and translation in dendrites
- Chapter 6 Organization and regulation of the postsynaptic density
- Chapter 7 Subcellular distribution of neurotransmitter receptors and voltage-gated ion channels
- Chapter 8 Neurotransmitter-gated ion channels in dendrites
- Chapter 9 Dendritic voltage-gated ion channels
- Chapter 10 Biochemical compartmentalization in dendrites
- Chapter 11 Spine calcium signaling
- Chapter 12 An historical perspective on modeling dendrites
- Chapter 13 A theoretical view of the neuron as a plastic input-output device
- Chapter 14 Dendritic integration
- Chapter 15 Dendrites as transmitters
- Chapter 16 Why have dendrites?
- Chapter 17 Short stories about small brains
- Chapter 18 Functional plasticity at dendritic synapses
- Chapter 19 Structural plasticity of dendrites
- Chapter 20 Dendrites and disease
- Chapter 21 Conclusion
- Index
Spine calcium signaling
Spine calcium signaling
- Chapter:
- (p.287) Chapter 11 Spine calcium signaling
- Source:
- Dendrites
- Author(s):
Adam Carter
Bernardo Sabatini
- Publisher:
- Oxford University Press
Spines are specialized cellular compartments found at high density on the dendrites of many neurons. Glutamatergic synapses are made onto spines, which house much of the local machinery necessary to readout and regulate synaptic activity. By providing a diffusionally isolated signaling compartment, spines allow neighboring synapses to operate independently. Stimulus-evoked increases in calcium concentration within spines trigger many forms of synaptic plasticity and can influence local excitability and morphology. This chapter focuses on the mechanisms of calcium handling and signaling within individual spines.
Keywords: calcium signaling, cellular compartments, glutamatergic synapses, synaptic activity, synaptic plasticity, calcium concentration
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- Title Pages
- Foreword
- Preface
- Contributors
- Abbreviations
- Chapter 1 Dendrite structure
- Chapter 2 Evolution and scaling of dendrites
- Chapter 3 Dendrite development
- Chapter 4 Molecular determinants of dendrite and spine development
- Chapter 5 RNA targeting, trafficking, and translation in dendrites
- Chapter 6 Organization and regulation of the postsynaptic density
- Chapter 7 Subcellular distribution of neurotransmitter receptors and voltage-gated ion channels
- Chapter 8 Neurotransmitter-gated ion channels in dendrites
- Chapter 9 Dendritic voltage-gated ion channels
- Chapter 10 Biochemical compartmentalization in dendrites
- Chapter 11 Spine calcium signaling
- Chapter 12 An historical perspective on modeling dendrites
- Chapter 13 A theoretical view of the neuron as a plastic input-output device
- Chapter 14 Dendritic integration
- Chapter 15 Dendrites as transmitters
- Chapter 16 Why have dendrites?
- Chapter 17 Short stories about small brains
- Chapter 18 Functional plasticity at dendritic synapses
- Chapter 19 Structural plasticity of dendrites
- Chapter 20 Dendrites and disease
- Chapter 21 Conclusion
- Index