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Dendrites$
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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2007

Print ISBN-13: 9780198566564

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198566564.001.0001

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Spine calcium signaling

Spine calcium signaling

Chapter:
(p.287) Chapter 11 Spine calcium signaling
Source:
Dendrites
Author(s):

Adam Carter

Bernardo Sabatini

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198566564.003.0011

Spines are specialized cellular compartments found at high density on the dendrites of many neurons. Glutamatergic synapses are made onto spines, which house much of the local machinery necessary to readout and regulate synaptic activity. By providing a diffusionally isolated signaling compartment, spines allow neighboring synapses to operate independently. Stimulus-evoked increases in calcium concentration within spines trigger many forms of synaptic plasticity and can influence local excitability and morphology. This chapter focuses on the mechanisms of calcium handling and signaling within individual spines.

Keywords:   calcium signaling, cellular compartments, glutamatergic synapses, synaptic activity, synaptic plasticity, calcium concentration

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