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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2007

Print ISBN-13: 9780198566564

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198566564.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 22 January 2021

A theoretical view of the neuron as a plastic input-output device

A theoretical view of the neuron as a plastic input-output device

(p.321) Chapter 13 A theoretical view of the neuron as a plastic input-output device

Ithai Rabinowitch

Michael London

Idan Segev

Oxford University Press

Wilfrid Rall developed the theoretical foundations for understanding dendritic function almost fifty years ago. Since then his theory has been intensely employed and extended in order to explore the biophysical principles that link together the structure, physiology, and function of dendrites. This chapter highlights some of the main insights that were gained from this theory, specifically emphasizing the relationship between the local activation of a synapse on a dendrite and the overall synaptic activity in the neuron. It discusses the contribution of a single synapse out of numerous active synapses to a neuron's firing pattern and describes a new measure to quantify the efficacy of a single synapse, using tools borrowed from information theory. It reviews the local and global aspects of the electrical activity in dendrites, and explores the effect of local versus global mechanisms of a specific form of synaptic plasticity, homeostatic synaptic plasticity.

Keywords:   dendritic function, neuron, synaptic activity, information theory, electrical activity, synaptic plasticity

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