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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2007

Print ISBN-13: 9780198566564

Published to Oxford Scholarship Online: March 2012

DOI: 10.1093/acprof:oso/9780198566564.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 07 March 2021

Functional plasticity at dendritic synapses

Functional plasticity at dendritic synapses

(p.465) Chapter 18 Functional plasticity at dendritic synapses

Zachary F. Mainen

Larry F. Abbott

Oxford University Press

Most synapses are made onto dendrites, and most excitatory connections are made onto dendritic spines. Synaptic plasticity is thus an intrinsically dendritic phenomenon, but the functional significance of the structural, electrical, and molecular properties of dendrites for synaptic plasticity is still very poorly understood. Do dendrites have a computational or cell biological role in the modification of synaptic strength that is more than circumstantial? This chapter aims to summarize experimental data and theoretical considerations that may be relevant to the role of dendrites in synaptic plasticity. The focus is on associative Hebbian synaptic plasticity, including spike-timing-dependent forms, mediated by NMDA receptor activation.

Keywords:   dendritic spines, synaptic plasticity, NMDA receptor activation, dendritic synapses, functional plasticity, synaptic strength

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