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Computational Molecular Evolution$
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Ziheng Yang

Print publication date: 2006

Print ISBN-13: 9780198567028

Published to Oxford Scholarship Online: April 2010

DOI: 10.1093/acprof:oso/9780198567028.001.0001

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Molecular clock and estimation of species divergence times

Molecular clock and estimation of species divergence times

(p.223) 7 Molecular clock and estimation of species divergence times
Computational Molecular Evolution


Oxford University Press

This chapter focuses on statistical methods for testing the clock hypothesis, and on likelihood and Bayesian methods for dating species divergence events under global and local clock models. In such an analysis, fossils are used to calibrate the clock, that is, to translate sequence distances into absolute geological times and substitution rates. A similar situation concerns viral genes, which evolve so fast that changes are observed over the years. Then one can use the dates at which the sequences are determined to calibrate the clock and to estimate divergence times, using essentially the same techniques as discussed here.

Keywords:   molecular clock, clock tests, fossils, global clock models, local clock models

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