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Aging of the Genome – The dual role of DNA in life and death - Oxford Scholarship Online
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Aging of the Genome: The dual role of DNA in life and death

Jan Vijg


Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. This book critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides a synthesis of current research, as well as a look ahead to the ... More

Keywords: aging, genome, DNA mutations, somatic cells, technology, genomic instability, cause of aging, genome functioning, complex organisms, systems biology

Bibliographic Information

Print publication date: 2007 Print ISBN-13: 9780198569237
Published to Oxford Scholarship Online: April 2010 DOI:10.1093/acprof:oso/9780198569237.001.0001


Affiliations are at time of print publication.

Jan Vijg, author
Buck Institute for Age Research, Novato, California, USA