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Aging of the GenomeThe dual role of DNA in life and death$
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Jan Vijg

Print publication date: 2007

Print ISBN-13: 9780198569237

Published to Oxford Scholarship Online: April 2010

DOI: 10.1093/acprof:oso/9780198569237.001.0001

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Genome structure and function

Genome structure and function

(p.57) 3 Genome structure and function
Aging of the Genome

Jan Vijg

Oxford University Press

This chapter focuses on those components of genome structure that have the potential to drive its demise in somatic cells over time, based on current knowledge of the sources of somatic damage in aging organisms and mechanisms of genomic instability. To this end, genome structure and organization are addressed at three levels: first, DNA primary structure and sequence; second, higher-order DNA structure; and third, nuclear architecture. In all cases the focus is on the impact of these structural levels on cellular function, especially patterns of regulation of gene transcription.

Keywords:   DNA primary structure, aging, nuclear architecture, gene transcription

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