Jump to ContentJump to Main Navigation
Aging of the GenomeThe dual role of DNA in life and death$
Users without a subscription are not able to see the full content.

Jan Vijg

Print publication date: 2007

Print ISBN-13: 9780198569237

Published to Oxford Scholarship Online: April 2010

DOI: 10.1093/acprof:oso/9780198569237.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 08 December 2021

Genome structure and function

Genome structure and function

Chapter:
(p.57) 3 Genome structure and function
Source:
Aging of the Genome
Author(s):

Jan Vijg

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198569237.003.0003

This chapter focuses on those components of genome structure that have the potential to drive its demise in somatic cells over time, based on current knowledge of the sources of somatic damage in aging organisms and mechanisms of genomic instability. To this end, genome structure and organization are addressed at three levels: first, DNA primary structure and sequence; second, higher-order DNA structure; and third, nuclear architecture. In all cases the focus is on the impact of these structural levels on cellular function, especially patterns of regulation of gene transcription.

Keywords:   DNA primary structure, aging, nuclear architecture, gene transcription

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .