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Aging of the GenomeThe dual role of DNA in life and death$
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Jan Vijg

Print publication date: 2007

Print ISBN-13: 9780198569237

Published to Oxford Scholarship Online: April 2010

DOI: 10.1093/acprof:oso/9780198569237.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 27 February 2021

Genome instability and accelerated aging

Genome instability and accelerated aging

(p.151) 5 Genome instability and accelerated aging
Aging of the Genome

Jan Vijg

Oxford University Press

The almost general consensus that aging is caused by the accumulation of unrepaired somatic damage has yielded models for aging based on the inactivation or weakening of somatic maintenance systems. Almost all these models are based on human and mouse mutants harbouring defects in genome maintenance. This chapter discusses such models, their molecular basis, the possible nature of the pro-aging processes underlying the phenotypes observed, and their validity in representing genuine aging processes as they take place in normal animals.

Keywords:   premature aging, accelerated aging, genome maintenance, aging process

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