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Aging of the GenomeThe dual role of DNA in life and death$
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Jan Vijg

Print publication date: 2007

Print ISBN-13: 9780198569237

Published to Oxford Scholarship Online: April 2010

DOI: 10.1093/acprof:oso/9780198569237.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 28 February 2021

The aging genome

The aging genome

(p.181) 6 The aging genome
Aging of the Genome

Jan Vijg

Oxford University Press

The emergence on the stage of DNA damage immediately raises the question of whether this type of genome alteration can itself be a cause of aging, or its molecular consequences in the form of mutations; that is, changes in DNA-sequence content. In addition, the recent realization that epigenomic modifications should also be considered as genuine changes in the genetic code introduces yet another potentially pro-aging type of genome alteration. Like DNA-sequence alterations, epigenomic changes are now considered as causes of cancer. This chapter considers the types of genome alteration that occur spontaneously in organisms, and their frequencies in aging cells and tissues.

Keywords:   DNA damage, aging process, DNA sequence

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