Jump to ContentJump to Main Navigation
Aging of the GenomeThe dual role of DNA in life and death$
Users without a subscription are not able to see the full content.

Jan Vijg

Print publication date: 2007

Print ISBN-13: 9780198569237

Published to Oxford Scholarship Online: April 2010

DOI: 10.1093/acprof:oso/9780198569237.001.0001

Show Summary Details
Page of

PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 01 March 2021

A genomic limit to life?

A genomic limit to life?

(p.289) 8 A genomic limit to life?
Aging of the Genome

Jan Vijg

Oxford University Press

A model, presented in Chapter 7, tentatively explains how random mutations can lead not only to cancer, but also to reduced function of the highly differentiated cells in vertebrates. Aging would then be the result of the ultimate failure of genome maintenance in preventing increased noise in the execution of various cellular programs due to accumulating errors in the information content of the genome. However, this model remains untested and could be wrong. Instead, aging could be partially or wholly due to a combination of other processes, most notably increased damage to cellular macromolecules, which may not be restricted to DNA, and the responses to their adverse effects. This chapter discusses the consequences of a scenario in which aging is predominantly a result of random, irreversible alterations in the somatic genome, and how that would impact our prospects to intervene and possibly retard or reverse aging-related cellular degeneration and organismal death.

Keywords:   aging process, genomic instability, cellular degeneration, organismal death

Oxford Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs , and if you can't find the answer there, please contact us .