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Supportive Care in Heart Failure$
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James Beattie and Sarah Goodlin

Print publication date: 2008

Print ISBN-13: 9780198570288

Published to Oxford Scholarship Online: November 2011

DOI: 10.1093/acprof:oso/9780198570288.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2020. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 26 September 2020

Heart Failure: Pathophysiology

Heart Failure: Pathophysiology

(p.27) Chapter 3 Heart Failure: Pathophysiology
Supportive Care in Heart Failure

Yasuhiro Ikeda

Takeshi Yamamoto

Masafumi Yano

Masunori Matsuzaki

Oxford University Press

This chapter considers the state of knowledge in the pathophysiology of heart failure (HF). In particular, it reviews the pathophysiological characteristics of HF, and describes the link between these features and recent advances in the molecular basis of HF. The features of HF can be classified into several categories according to their pathophysiological characteristics: acute or chronic HF; systolic or diastolic failure; right-sided or left-sided HF; and high output or low output failure. These characteristics are discussed in detail. Factors that aggravate HF include increased uptake of water or sodium, infection, stress, poor blood pressure control, non-compliance with oral medication, transient cardiac arrhythmia including atrial fibrillation and tachycardia, anemia, and renal dysfunction, advanced aging, sleep apnea syndrome, lethal cardiac arrhythmia, and myocardial disease secondary to systemic disease such as amyloidosis or sarcoidosis. Finally, the future clinical and research implications are highlighted.

Keywords:   heart failure, pathophysiology, features, infection, stress, myocardial disease, cardiac arrhythmia, poor blood pressure, anemia, renal dysfunction

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