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Addiction and ChoiceRethinking the relationship$
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Nick Heather and Gabriel Segal

Print publication date: 2016

Print ISBN-13: 9780198727224

Published to Oxford Scholarship Online: November 2016

DOI: 10.1093/acprof:oso/9780198727224.001.0001

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Assessing drug choice in human addiction

Assessing drug choice in human addiction

Costs, benefits, and findings from current research paradigms

Chapter:
(p.186) Chapter 11 Assessing drug choice in human addiction
Source:
Addiction and Choice
Author(s):

Scott J. Moeller

Rita Z. Goldstein

Publisher:
Oxford University Press
DOI:10.1093/acprof:oso/9780198727224.003.0011

Individuals with drug addiction pursue and choose drug-related reinforcers over other pleasant, non-drug reinforcers, and the extent of such drug-related choice often correlates with addiction severity. However, assessing the propensity to choose drugs in human addiction poses special challenges, including issues of ethics and generalizability. This chapter first provides an overview of classical paradigms of drug choice and cue reactivity, which are often employed in active users and abstinent users respectively, and describe some of their strengths and limitations. In an attempt to address these limitations, we developed and implemented recent behavioral and neuroimaging paradigms that model actual choice behavior while using drug-related stimuli (pictures) instead of actual drugs. We suggest that such simulated drug choice can reveal novel neurocognitive markers inaccessible with other paradigms, helping to clarify the addiction process and potentially predict key clinical outcomes.

Keywords:   addiction, drug choice, cue reactivity, neuroimaging paradigms, ethics, clinical outcomes

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