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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 22 January 2021

Spine calcium signaling

Spine calcium signaling

(p.325) Chapter 11 Spine calcium signaling

Adam Carter

Bernardo Sabatini

Oxford University Press

Spines are specialized cellular compartments found at high density on the dendrites of many neurons. Glutamatergic synapses are made onto spines, which house much of the machinery needed to read out synaptic activity. By providing a diffusionally isolated signaling compartment, spines allow neighboring synapses to operate independently. Stimulus-evoked increases in spine calcium trigger many forms of synaptic plasticity and can influence local excitability and morphology. This chapter focuses on the mechanisms of calcium handling and signaling within individual spines.

Keywords:   dendrite, spine, synapse, calcium, signaling, plasticity, excitability

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