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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 January 2021

Dendritic integration in vivo

Dendritic integration in vivo

(p.399) Chapter 13 Dendritic integration in vivo

Lucy Palmer

Masanori Murayama

Matthew Larkum

Oxford University Press

If dendritic integration is important for understanding the input-output function of neurons, then understanding how dendrites integrate information in the behaving organism should be seen as one of the crucial milestones in neuroscience. Most of what we currently know about dendritic integration has been determined in vitro and we are only just beginning to reveal how dendrites function in the intact organism. This is no easy feat as the properties of dendrites in vivo are influenced additionally by various factors such as increased synaptic input, different channel activation states, input arriving from varying information pathways, and neuromodulation. This chapter reviews the influence of these factors on dendritic activity in vivo and highlights what has been experimentally determined about dendritic integration in the intact organism to date.

Keywords:   dendritic integration, in vivo, dendrite, activation state, neuromodulation, input–output function, behaving organism

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