- Title Pages
- Foreword to the Third Edition
- Preface to the Third Edition
- List of Contributors
- List of Abbreviations
- Chapter 1 Dendrite structure
- Chapter 2 Evolution and scaling of dendrites
- Chapter 3 Dendrite development
- Chapter 4 Molecular determinants of dendrite and spine development
- Chapter 5 Local translation in dendrites
- Chapter 6 Structure and molecular organization of the postsynaptic density
- Chapter 7 Subcellular distribution of ligand- and voltage-gated ion channels
- Chapter 8 Neurotransmitter-gated ion channels in dendrites
- Chapter 9 Dendritic voltage-gated ion channels
- Chapter 10 Biochemical compartmentalization in dendrites
- Chapter 11 Spine calcium signaling
- Chapter 12 Principles of dendritic integration
- Chapter 13 Dendritic integration in vivo
- Chapter 14 Modeling dendrites: a personal perspective
- Chapter 15 A theoretical view of the neuron as an input–output computing device
- Chapter 16 Toward a simplified model of an active dendritic tree
- Chapter 17 Modeling dendrite shape
- Chapter 18 Functional plasticity at dendritic synapses
- Chapter 19 Structural plasticity in dendrites and spines
- Chapter 20 Molecular signaling during plasticity of dendritic spines
- Chapter 21 Dendrites as transmitters
- Chapter 22 Dendritic connectomics
- Chapter 23 Linking dendritic processing to computation and behavior in invertebrates
- Chapter 24 Dendrites and disease
- Chapter 25 The future of dendrite research
- Index
Dendritic integration in vivo
Dendritic integration in vivo
- Chapter:
- (p.399) Chapter 13 Dendritic integration in vivo
- Source:
- Dendrites
- Author(s):
Lucy Palmer
Masanori Murayama
Matthew Larkum
- Publisher:
- Oxford University Press
If dendritic integration is important for understanding the input-output function of neurons, then understanding how dendrites integrate information in the behaving organism should be seen as one of the crucial milestones in neuroscience. Most of what we currently know about dendritic integration has been determined in vitro and we are only just beginning to reveal how dendrites function in the intact organism. This is no easy feat as the properties of dendrites in vivo are influenced additionally by various factors such as increased synaptic input, different channel activation states, input arriving from varying information pathways, and neuromodulation. This chapter reviews the influence of these factors on dendritic activity in vivo and highlights what has been experimentally determined about dendritic integration in the intact organism to date.
Keywords: dendritic integration, in vivo, dendrite, activation state, neuromodulation, input–output function, behaving organism
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- Title Pages
- Foreword to the Third Edition
- Preface to the Third Edition
- List of Contributors
- List of Abbreviations
- Chapter 1 Dendrite structure
- Chapter 2 Evolution and scaling of dendrites
- Chapter 3 Dendrite development
- Chapter 4 Molecular determinants of dendrite and spine development
- Chapter 5 Local translation in dendrites
- Chapter 6 Structure and molecular organization of the postsynaptic density
- Chapter 7 Subcellular distribution of ligand- and voltage-gated ion channels
- Chapter 8 Neurotransmitter-gated ion channels in dendrites
- Chapter 9 Dendritic voltage-gated ion channels
- Chapter 10 Biochemical compartmentalization in dendrites
- Chapter 11 Spine calcium signaling
- Chapter 12 Principles of dendritic integration
- Chapter 13 Dendritic integration in vivo
- Chapter 14 Modeling dendrites: a personal perspective
- Chapter 15 A theoretical view of the neuron as an input–output computing device
- Chapter 16 Toward a simplified model of an active dendritic tree
- Chapter 17 Modeling dendrite shape
- Chapter 18 Functional plasticity at dendritic synapses
- Chapter 19 Structural plasticity in dendrites and spines
- Chapter 20 Molecular signaling during plasticity of dendritic spines
- Chapter 21 Dendrites as transmitters
- Chapter 22 Dendritic connectomics
- Chapter 23 Linking dendritic processing to computation and behavior in invertebrates
- Chapter 24 Dendrites and disease
- Chapter 25 The future of dendrite research
- Index