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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 January 2021

Modeling dendrite shape

Modeling dendrite shape

(p.487) Chapter 17 Modeling dendrite shape

Hermann Cuntz

Oxford University Press

The functional role of voltage-gated channels has been extensively studied in computational models of dendrites, but the role of dendritic shape itself has long eluded a rigorous quantitative analysis because of a lack of corresponding models. Several novel modeling techniques have recently emerged that enable the generation of synthetic dendritic trees for most types of neurons. These models are useful for studying how aspects of dendritic computation depend on specific features of dendritic morphology and their impact in pathological changes of dendritic shape. The models also allow one to study general principles and relations of morphological parameters in dendritic trees and to understand circuit formation during development. With detailed models of single neurons now reaching a high degree of biological realism, it will be valuable to implement such models in simulations of entire neural circuits.

Keywords:   dendrites, computational model, dendritic shape, morphological parameters, circuit formation, neural circuits

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