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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 25 January 2021

Structural plasticity in dendrites and spines

Structural plasticity in dendrites and spines

(p.557) Chapter 19 Structural plasticity in dendrites and spines

Tobias Bonhoeffer

Pico Caroni

Oxford University Press

This chapter examines some of the most important studies on the topic of structural plasticity in dendrites and spines, placing them into the context of information storage in the brain. The chapter starts with an assessment of the classical literature, which mostly relied on conventional light and electron microscopy. However, most emphasis in this chapter is on studies using state-of-the-art imaging approaches, which allow microscopical structural changes to be followed over time, including in awake animals performing complex behavioral tasks. The chapter ends with five particularly important open questions, providing an outlook into the future, and a discussion of where research on structural plasticity in relationship to synaptic plasticity and memory could stand in a few years’ time.

Keywords:   dendrite, spine, microscopy, imaging, behavioral tasks, memory, synaptic plasticity

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