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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 January 2021

Molecular signaling during plasticity of dendritic spines

Molecular signaling during plasticity of dendritic spines

(p.581) Chapter 20 Molecular signaling during plasticity of dendritic spines

Ryohei Yasuda

Oxford University Press

Intracellular signaling in dendrites of pyramidal neurons is responsible for synaptic plasticity related to learning and memory. It is mediated by a biochemical network consisting of hundreds of signaling molecules extensively connecting to each other. The signaling processes for synaptic plasticity are initiated in a dendritic spine and targeted to multiple subcellular compartments in the stimulated spine and surrounding dendritic segment. This in turn causes a rapid modification of the structure and function of the stimulated spine. Some signals spread over much longer distances, influencing the properties of their parent dendritic branch or the nucleus to regulate gene transcription. Due to the complicated morphology of dendrites, the biochemical reaction is compartmentalized in different length scales, determining the length scales of different forms of synaptic plasticity and meta-plasticity. The recent development of optical techniques has allowed researchers to image signaling activity in dendrites at the single-spine level and this provided many insights into how the spatio-temporal dynamics of intracellular signaling is organized during synaptic plasticity.

Keywords:   intracellular signaling, synaptic plasticity, dendrites, spines, signaling molecules, gene transcription

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