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Greg Stuart, Nelson Spruston, and Michael Häusser

Print publication date: 2016

Print ISBN-13: 9780198745273

Published to Oxford Scholarship Online: May 2016

DOI: 10.1093/acprof:oso/9780198745273.001.0001

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PRINTED FROM OXFORD SCHOLARSHIP ONLINE (oxford.universitypressscholarship.com). (c) Copyright Oxford University Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in OSO for personal use. date: 18 January 2021

Dendritic connectomics

Dendritic connectomics

(p.623) Chapter 22 Dendritic connectomics

Kevin M. Boergens

Manuel Berning

Moritz Helmstaedter

Oxford University Press

Dendrites host a number of biophysical mechanisms for the complex interaction of input synapses. Some of these interactions are enhanced by the spatial patterning of active synapses on the target dendrite. To understand the nature of dendritic signal transformations, it would be ideal to map out all incoming synapses and determine the location and functional properties of their source neurons. Only in the last decade have methods based on three-dimensional electron microscopy become available to make such a microscopically precise large-scale structural synaptic mapping realistic. This chapter summarizes these methodological advances, reviews recent discoveries of precise dendritic input mapping in the mouse retina, and outlines the steps needed to search for synaptic patterning in the cerebral cortex. Obtaining a neuron’s complete synaptic input map-its dendritic connectome-will provide the link between the biophysics of complex signal transformations in dendrites and their algorithmic meaning in the context of the brain’s neuronal circuits.

Keywords:   connectomics, three-dimensional electron microscopy, synapse, dendrite, synaptic mapping, mouse retina, dendritic connectome, neuronal circuits

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